Application of Lipids in Hot Melt Extrusion Technology

Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism nanoparticulate approach, modifying the release, binders, permeation enhancers, transfection agents etc. alone or combination polymers increasingly being hot melt extrusion (HME) technology preparation controlled release formulations, solid dispersions, self-emulsifying systems, semi-solid lipid nanoparticles and others. Properties like melting temperature, viscosity, ability to extrude at temperature load high doses favor use lipids HME technology. This review emphasizes variety applications technology.
 Keywords: Lipids, Hot extrusion, solubility, bioavailability, parameters.